PDZRN3

Across TCGA cell cohorts, PDZRN3 mutation is significantly associated with the RNA expression of many other genes, with 602 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDZRN3-associated genes across cancer lineages are BBS7, FTMT, and HELT. Each is linked with PDZRN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZRN3-to-partner and partner-to-PDZRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBS7 grouped by PDZRN3-low versus PDZRN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZRN3→partner) and Y-score (partner→PDZRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS7 →	+0.560	+3.364	.006	.002	3	3
BLOOD_Lymphoma	FTMT →	+0.158	+3.925	<.001	.006	3	2
CNS	HELT →	+0.030	+4.321	<.001	.009	3	2
STOMACH	DAZ2 →	+0.888	+3.263	<.001	.001	3	2
BLOOD_Lymphoma	PRR23B →	+0.002	+3.925	<.001	.006	3	2
BLOOD_Lymphoma	ROPN1 →	+0.036	+4.121	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 602 associations by consensus.

BBS7 by PDZRN3 expression — LARGE_INTESTINE

Explore this box plot interactively →