PDZD3

Across TCGA patient cohorts, PDZD3 protein abundance is significantly associated with the protein abundance of many other proteins, with 3,103 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PDZD3-associated proteins across cancer lineages are ECHDC2, RPL34, and MME. Each is linked with PDZD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD3-to-partner and partner-to-PDZD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDZD3 versus ECHDC2 in CCRCC, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD3→partner) and Y-score (partner→PDZD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ECHDC2 →	+0.655	+0.455	<.001	<.001	3	2
CCRCC	RPL34 →	-0.479	-0.341	<.001	<.001	3	2
CCRCC	MME →	+0.428	+0.362	<.001	<.001	3	1
CCRCC	MMUT →	+0.216	+0.399	<.001	<.001	3	1
CCRCC	MORC3 →	-0.136	-0.393	.001	<.001	3	1
CCRCC	MPC1 →	+0.570	+0.302	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,103 associations by consensus.

PDZD3 vs ECHDC2 — CCRCC

Explore this scatter interactively →