PDZD3

Across TCGA patient cohorts, PDZD3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD3-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and JNK_pT183_Y185. Each is linked with PDZD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZD3-to-partner and partner-to-PDZD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PDZD3-low versus PDZD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD3→partner) and Y-score (partner→PDZD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.718	+2.341	<.001	.003	3	3
UCEC	4E-BP1 →	+0.243	+3.199	.014	.009	3	3
UCEC	JNK_pT183_Y185 →	-0.220	-3.087	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.136	-1.980	.012	.030	3	2
UCEC	p70-S6K_pT389 →	-0.185	-3.169	.008	.018	3	2
SKCM	PCNA →	+0.493	+3.169	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by PDZD3 expression — UCEC

Explore this box plot interactively →