PDZD2

Across TCGA patient cohorts, PDZD2 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD2-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and IGFBP2. Each is linked with PDZD2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PDZD2-to-partner and partner-to-PDZD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PDZD2-low versus PDZD2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD2→partner) and Y-score (partner→PDZD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.035	+2.467	<.001	<.001	3	6
STAD	PCNA →	+0.309	+2.321	<.001	.004	3	6
LUSC	IGFBP2 →	-1.035	-1.990	.001	.031	3	4
UCEC	Cyclin-B1 →	+0.441	+2.392	.001	<.001	3	4
UCEC	ATM →	-0.454	-1.861	<.001	.001	3	4
STAD	GAPDH →	+0.330	+2.807	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Caspase-7-cleavedD198 by PDZD2 expression — COAD

Explore this box plot interactively →