PDZD2

Across TCGA cell cohorts, PDZD2 mutation is significantly associated with the RNA expression of many other genes, with 643 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDZD2-associated genes across cancer lineages are CLMN, CRYBA1, and KLRC3. Each is linked with PDZD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZD2-to-partner and partner-to-PDZD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLMN grouped by PDZD2-low versus PDZD2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD2→partner) and Y-score (partner→PDZD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLMN →	+1.019	+3.643	<.001	<.001	3	3
SOFT_TISSUE	CRYBA1 →	+0.530	+3.569	<.001	.006	2	3
BLOOD_Myeloma	KLRC3 →	+0.035	+3.906	.001	.009	3	2
PANCREAS	DRD3 →	+0.005	+4.614	<.001	.004	3	2
BREAST	TRIM62 →	+0.723	+3.372	.003	.002	3	2
SKIN	ZCCHC2 →	+0.507	+3.067	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 643 associations by consensus.

CLMN by PDZD2 expression — BLOOD_Leukemia

Explore this box plot interactively →