PDYN-AS1

Across TCGA pan-cancer cohorts, PDYN-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PDYN-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PDYN-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDYN-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and PAAD show a favorable association.

LGG, BRCA, and MESO are the cancer types where PDYN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.270	0.502	<.001	47	view →
BRCA	OS	Tertile	All	0.952	0.966	.033	42	view →
MESO	OS	Median	All	0.674	0.432	.002	31	view →
LIHC	DFS	Quartile	All	0.431	0.572	.003	28	view →
UCEC	OS	Quartile	II,III,IV	0.727	0.882	.001	28	view →
PAAD	OS	Tertile	All	0.701	0.384	.003	25	view →
KIRP	DFS	Median	All	0.954	0.868	.003	25	view →
THCA	DFS	Tertile	IV	0.564	0.865	.004	21	view →
LUAD	DFS	Tertile	III,IV	0.497	0.714	.011	18	view →
THYM	DFS	Quartile	All	0.711	0.914	.003	16	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	9	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

PDYN-AS1–LGG (DFS)

Open the LGG breakdown →