PDXP

Across TCGA pan-cancer cohorts, PDXP mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PDXP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PDXP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PDXP is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where PDXP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDXP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.590	<.001	11	view →
CCRCC	Male	II,III,IV	+0.352	<.001	11	view →
LUAD	Female	II,III,IV	−0.484	<.001	9	view →
LSCC	Male	II,III,IV	−0.312	<.001	8	view →
PDAC	Female	II,III,IV	−0.718	<.001	7	view →
HNSC	Male	II,III,IV	−0.232	<.001	6	view →
OV	All	All	−0.418	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PDXP–COAD

Open the COAD breakdown →