PDXK

Across TCGA patient cohorts, PDXK mutation is significantly associated with the RNA expression of many other genes, with 3,798 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDXK-associated genes across cancer lineages are CCDC88C, C18orf25, and SAP30. Each is linked with PDXK in more than 1 cancer types. Because this analysis shows association rather than direction, both PDXK-to-partner and partner-to-PDXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC88C grouped by PDXK-low versus PDXK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDXK→partner) and Y-score (partner→PDXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC88C →	+0.391	+3.010	.001	<.001	3	2
UCEC	C18orf25 →	+0.325	+1.505	.003	.001	3	2
UCEC	SAP30 →	+0.389	+1.869	.004	.004	3	2
UCEC	PRMT9 →	+0.388	+4.386	<.001	<.001	3	2
UCEC	PRRC1 →	+0.472	+1.874	<.001	<.001	3	2
UCEC	C9orf64 →	+0.620	+1.720	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,798 associations by consensus.

CCDC88C by PDXK expression — UCEC

Explore this box plot interactively →