PDXK

Across TCGA patient cohorts, PDXK mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDXK-associated genes across cancer lineages are Notch1, Caspase-8, and Cyclin-B1. Each is linked with PDXK in more than 1 cancer types. Because this analysis shows association rather than direction, both PDXK-to-partner and partner-to-PDXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PDXK-low versus PDXK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDXK→partner) and Y-score (partner→PDXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.115	+1.594	.009	.010	3	2
UCEC	Caspase-8 →	-0.222	-1.807	.005	.003	3	2
UCEC	Cyclin-B1 →	+0.519	+2.115	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.084	-1.340	.007	.015	3	1
UCEC	eIF4E →	+0.196	+3.713	.003	<.001	3	1
UCEC	ERCC1 →	-0.131	-1.973	.016	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Notch1 by PDXK expression — UCEC

Explore this box plot interactively →