PDXDC1

Across TCGA pan-cancer cohorts, PDXDC1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDXDC1 data layer compared with 21 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PDXDC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PDXDC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, LUSC, and COAD are the cancer types where PDXDC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	III,IV	0.118	0.615	.003	9	view →
LUSC	OS	Median	II,III,IV	0.233	0.631	.046	6	view →
COAD	DFS	Median	All	0.167	0.564	.048	5	view →
UCEC	DFS	Median	All	0.907	0.619	.035	4	view →
KIRP	OS	Median	II,III,IV	0.216	0.771	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDXDC1–LIHC (OS)

Open the LIHC breakdown →