PDXDC1

Across TCGA cell cohorts, PDXDC1 mutation is significantly associated with the RNA expression of many other genes, with 688 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDXDC1-associated genes across cancer lineages are SMIM9, KRTAP21-2, and ELOA3P. Each is linked with PDXDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDXDC1-to-partner and partner-to-PDXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM9 grouped by PDXDC1-low versus PDXDC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDXDC1→partner) and Y-score (partner→PDXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMIM9 →	+0.029	+3.734	<.001	.006	3	2
LARGE_INTESTINE	KRTAP21-2 →	+0.037	+2.345	<.001	.007	3	2
LARGE_INTESTINE	ELOA3P →	+0.075	+1.982	.001	.009	3	2
LUNG_NSCLC_LUSC	IL21 →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CLEC4D →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PNMA6F →	+0.013	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 688 associations by consensus.

SMIM9 by PDXDC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →