PDSS1

Across TCGA patient cohorts, PDSS1 mutation is significantly associated with the RNA expression of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDSS1-associated genes across cancer lineages are MIR4450, MIR1185-2, and RNU5E-9P. Each is linked with PDSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDSS1-to-partner and partner-to-PDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4450 grouped by PDSS1-low versus PDSS1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDSS1→partner) and Y-score (partner→PDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4450 →	+0.605	+5.421	<.001	.005	3	2
UCEC	MIR1185-2 →	+0.239	+4.470	<.001	.004	3	2
UCEC	RNU5E-9P →	+0.328	+4.470	<.001	.004	3	2
COAD	SYPL1P1 →	+0.121	+4.693	<.001	.007	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
UCEC	MIR6750 →	+0.797	+2.561	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

MIR4450 by PDSS1 expression — READ

Explore this box plot interactively →