PDSS1

Across TCGA cell cohorts, PDSS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,581 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDSS1-associated GO terms across cancer lineages are DNA replication initiation, Pseudouridine synthesis, and 'de novo' cotranslational protein folding. Each is linked with PDSS1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PDSS1-to-partner and partner-to-PDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by PDSS1-low versus PDSS1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDSS1→partner) and Y-score (partner→PDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA replication initiation →	+0.217	+1.544	<.001	<.001	3	18
STOMACH	Pseudouridine synthesis →	+0.105	+0.974	<.001	.002	3	18
BONE	'de novo' cotranslational protein folding →	+0.135	+1.526	<.001	.001	3	17
LIVER	'de novo' IMP biosynthetic process →	+0.166	+0.862	<.001	.005	3	17
BONE	Mitochondrial RNA metabolic process →	+0.098	+1.213	<.001	<.001	3	17
BLOOD_Myeloma	Negative regulation of DNA-templated DNA replication →	+0.154	+0.813	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,581 associations by consensus.

DNA replication initiation by PDSS1 expression — PANCREAS

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