PDSS1

Across TCGA cell cohorts, PDSS1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDSS1-associated genes across cancer lineages are SPATA31D1 and HNRNPCL4. Each is linked with PDSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDSS1-to-partner and partner-to-PDSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D1 grouped by PDSS1-low versus PDSS1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDSS1→partner) and Y-score (partner→PDSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.007	+5.813	<.001	<.001	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.060	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SPATA31D1 by PDSS1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →