PDS5B

Across TCGA patient cohorts, PDS5B protein abundance is significantly associated with the RNA expression of many other genes, with 19,314 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDS5B-associated genes across cancer lineages are GKAP1, EXOSC8, and DCUN1D2. Each is linked with PDS5B in more than 6 cancer types. Because this analysis shows association rather than direction, both PDS5B-to-partner and partner-to-PDS5B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDS5B versus GKAP1 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5B→partner) and Y-score (partner→PDS5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GKAP1 →	+0.830	+0.246	<.001	<.001	3	7
GBM	EXOSC8 →	+0.532	+0.324	<.001	<.001	3	7
LSCC	DCUN1D2 →	+0.668	+0.218	<.001	.001	3	7
HNSC	SUPT20H →	+0.547	+0.246	.005	.002	3	6
HNSC	MRPS31 →	+0.468	+0.218	.001	<.001	2	7
HNSC	KBTBD7 →	+0.799	+0.332	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,314 associations by consensus.

PDS5B vs GKAP1 — HNSC

Explore this scatter interactively →