PDS5B

Across TCGA patient cohorts, PDS5B mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDS5B-associated genes across cancer lineages are PDCD4, Shc_pY317, and ASNS. Each is linked with PDS5B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDS5B-to-partner and partner-to-PDS5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PDS5B-low versus PDS5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5B→partner) and Y-score (partner→PDS5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.427	-1.321	.001	.005	3	3
UCEC	Shc_pY317 →	-0.152	-2.321	<.001	<.001	3	3
COAD	ASNS →	+0.430	+3.321	.016	.009	3	3
COAD	ATM →	-0.568	-2.313	.001	.035	3	3
UCEC	14-3-3_beta →	-0.066	-1.253	.018	.049	3	2
COAD	eEF2 →	+0.365	+3.169	.006	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

PDCD4 by PDS5B expression — UCEC

Explore this box plot interactively →