PDS5B

Across TCGA cell cohorts, PDS5B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,152 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDS5B-associated GO terms across cancer lineages are Positive regulation of mitotic sister chromatid separation, Regulation of chromosome condensation, and Mitotic sister chromatid cohesion. Each is linked with PDS5B in more than 15 cancer types. Because this analysis shows association rather than direction, both PDS5B-to-partner and partner-to-PDS5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic sister chromatid separation grouped by PDS5B-low versus PDS5B-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5B→partner) and Y-score (partner→PDS5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of mitotic sister chromatid separation →	+0.147	+0.982	<.001	.002	3	16
SOFT_TISSUE	Regulation of chromosome condensation →	+0.154	+0.919	<.001	<.001	3	16
SOFT_TISSUE	Mitotic sister chromatid cohesion →	+0.123	+1.309	<.001	<.001	3	16
BLOOD_Lymphoma	Sister chromatid cohesion →	+0.126	+1.193	<.001	<.001	3	15
BLOOD_Lymphoma	Mitotic spindle assembly →	+0.103	+1.333	<.001	<.001	3	15
LUNG_SCLC	Protein localization to chromosome →	+0.088	+0.963	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,152 associations by consensus.

Positive regulation of mitotic sister chromatid separation by PDS5B expression — SOFT_TISSUE

Explore this box plot interactively →