PDS5B

Across TCGA cell cohorts, PDS5B mutation is significantly associated with the RNA expression of many other genes, with 1,158 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDS5B-associated genes across cancer lineages are MROH2B, SGSM3, and ARMC1. Each is linked with PDS5B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDS5B-to-partner and partner-to-PDS5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH2B grouped by PDS5B-low versus PDS5B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5B→partner) and Y-score (partner→PDS5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MROH2B →	+0.053	+5.339	<.001	<.001	3	2
LARGE_INTESTINE	SGSM3 →	+0.562	+2.743	.009	.001	3	2
LARGE_INTESTINE	ARMC1 →	+0.375	+2.043	.004	.008	3	2
LARGE_INTESTINE	GUCA1B →	+0.815	+3.321	.001	.003	3	2
LARGE_INTESTINE	ZIC5 →	+0.970	+3.321	.001	.003	3	2
LARGE_INTESTINE	FEM1A →	+0.626	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,158 associations by consensus.

MROH2B by PDS5B expression — OVARY

Explore this box plot interactively →