PDS5A

Across TCGA pan-cancer cohorts, PDS5A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PDS5A data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PDS5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PDS5A expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and CCRCC are the cancer types where PDS5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.919	.013	42	view →
UCEC	OS	Median	III,IV	1.000	0.433	.007	30	view →
CCRCC	OS	Median	IV	0.123	0.785	.009	11	view →
HNSC	DFS	Quartile	All	0.462	0.731	.029	5	view →
LSCC	DFS	Median	II,III,IV	1.000	0.834	.004	5	view →
PDAC	DFS	Tertile	IV	0.515	0.182	.024	4	view →
LUAD	OS	Median	II,III,IV	0.999	0.863	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PDS5A–COAD (DFS)

Open the COAD breakdown →