PDS5A

Across TCGA patient cohorts, PDS5A protein abundance is significantly associated with the RNA expression of many other genes, with 12,095 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDS5A-associated genes across cancer lineages are OIP5, EZH2, and RFC5. Each is linked with PDS5A in more than 7 cancer types. Because this analysis shows association rather than direction, both PDS5A-to-partner and partner-to-PDS5A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDS5A versus OIP5 in UCEC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5A→partner) and Y-score (partner→PDS5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.703	+0.247	<.001	<.001	3	8
HNSC	EZH2 →	+0.874	+0.173	.001	.008	3	8
LSCC	RFC5 →	+0.602	+0.188	<.001	<.001	3	8
HNSC	FBXO5 →	+0.855	+0.226	<.001	<.001	3	8
LSCC	KIF23 →	+0.792	+0.301	<.001	<.001	3	8
LSCC	FANCI →	+0.865	+0.272	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,095 associations by consensus.

PDS5A vs OIP5 — UCEC

Explore this scatter interactively →