PDS5A

Across TCGA patient cohorts, PDS5A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDS5A-associated genes across cancer lineages are eEF2, p62 Lck ligand, and PDCD4. Each is linked with PDS5A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDS5A-to-partner and partner-to-PDS5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PDS5A-low versus PDS5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5A→partner) and Y-score (partner→PDS5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.231	+1.700	.049	.040	3	3
UCEC	p62 Lck ligand →	+0.237	+1.817	.026	.015	3	3
UCEC	PDCD4 →	-0.492	-2.263	.001	<.001	3	3
UCEC	FoxM1 →	+0.168	+1.652	.049	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.170	-2.087	.002	.005	3	2
UCEC	MEK1 →	+0.533	+2.263	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by PDS5A expression — UCEC

Explore this box plot interactively →