PDS5A

Across TCGA cell cohorts, PDS5A mutation is significantly associated with the RNA expression of many other genes, with 1,711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDS5A-associated genes across cancer lineages are CD40LG, GPR101, and CHRNA4. Each is linked with PDS5A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDS5A-to-partner and partner-to-PDS5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by PDS5A-low versus PDS5A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDS5A→partner) and Y-score (partner→PDS5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CD40LG →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	GPR101 →	+0.015	+4.087	<.001	.009	3	1
BLOOD_Leukemia	CHRNA4 →	+0.023	+3.234	<.001	.008	3	1
BLOOD_Leukemia	RNF17 →	+0.154	+4.392	<.001	.005	3	1
BLOOD_Leukemia	GH2 →	+0.019	+3.969	<.001	.009	3	1
BLOOD_Leukemia	SPINK7 →	+0.040	+3.234	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,711 associations by consensus.

CD40LG by PDS5A expression — URINARY_TRACT

Explore this box plot interactively →