PDRG1

Across TCGA pan-cancer cohorts, PDRG1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PDRG1 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PDRG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PDRG1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where PDRG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.905	0.417	<.001	27	view →
GBM	DFS	Median	All	0.643	0.786	.003	12	view →
CCRCC	DFS	Tertile	III,IV	0.757	0.948	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PDRG1–LSCC (DFS)

Open the LSCC breakdown →