PDPR

Across TCGA pan-cancer cohorts, PDPR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PDPR data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PDPR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDPR expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

LSCC, UCEC, and GBM are the cancer types where PDPR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.602	0.927	.003	35	view →
UCEC	DFS	Quartile	II,III,IV	0.346	1.000	.006	20	view →
GBM	OS	Quartile	All	0.625	0.188	.014	4	view →
CCRCC	DFS	Quartile	All	0.635	0.893	.037	2	view →
PDAC	OS	Tertile	All	0.380	0.608	.028	2	view →
LUAD	OS	Quartile	All	1.000	0.767	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PDPR–LSCC (DFS)

Open the LSCC breakdown →