PDPN

Across TCGA patient cohorts, PDPN protein abundance is significantly associated with the RNA expression of many other genes, with 2,225 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDPN-associated genes across cancer lineages are WNT2, OSBPL10, and SERPINH1. Each is linked with PDPN in more than 2 cancer types. Because this analysis shows association rather than direction, both PDPN-to-partner and partner-to-PDPN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDPN versus WNT2 in OV, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPN→partner) and Y-score (partner→PDPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WNT2 →	+1.274	+1.271	.002	<.001	3	2
OV	OSBPL10 →	+0.671	+1.120	.004	.001	3	2
OV	SERPINH1 →	+0.945	+1.031	<.001	.001	3	2
GBM	TKTL2 →	-0.340	-0.915	.003	.009	3	2
OV	PPEF2 →	+0.067	+1.158	.008	.003	3	2
OV	MAP3K7CL →	+0.871	+1.358	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,225 associations by consensus.

PDPN vs WNT2 — OV

Explore this scatter interactively →