PDPN

Across TCGA patient cohorts, PDPN mutation is significantly associated with the RNA expression of many other genes, with 2,611 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDPN-associated genes across cancer lineages are RN7SKP60, PAQR3, and EFNA1. Each is linked with PDPN in more than 2 cancer types. Because this analysis shows association rather than direction, both PDPN-to-partner and partner-to-PDPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP60 grouped by PDPN-low versus PDPN-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPN→partner) and Y-score (partner→PDPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP60 →	+0.180	+6.018	<.001	.002	3	3
UCEC	PAQR3 →	+0.397	+2.238	.008	.006	3	2
UCEC	EFNA1 →	-0.749	-3.791	<.001	<.001	3	2
UCEC	FAXDC2 →	-0.707	-2.906	<.001	.001	3	2
UCEC	MOB1B →	+0.456	+1.890	.008	.005	3	2
COAD	RN7SL168P →	+0.556	+3.646	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,611 associations by consensus.

RN7SKP60 by PDPN expression — BLCA

Explore this box plot interactively →