PDPN

Across TCGA patient cohorts, PDPN mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDPN-associated genes across cancer lineages are ATM, eEF2, and A-Raf_pS299. Each is linked with PDPN in more than 1 cancer types. Because this analysis shows association rather than direction, both PDPN-to-partner and partner-to-PDPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PDPN-low versus PDPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPN→partner) and Y-score (partner→PDPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.602	-1.906	<.001	.016	3	2
UCEC	eEF2 →	+0.291	+1.906	.043	.016	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.999	.004	.035	3	1
UCEC	ERK2 →	+0.177	+3.459	.022	.005	3	1
UCEC	FoxM1 →	+0.240	+3.459	.021	.005	3	1
UCEC	HER3_pY1289 →	+0.072	+1.933	.037	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by PDPN expression — UCEC

Explore this box plot interactively →