PDPN

Across TCGA cell cohorts, PDPN mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDPN-associated genes across cancer lineages are ACCSL, CST9L, and OR4K2. Each is linked with PDPN in more than 1 cancer types. Because this analysis shows association rather than direction, both PDPN-to-partner and partner-to-PDPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACCSL grouped by PDPN-low versus PDPN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPN→partner) and Y-score (partner→PDPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACCSL →	+0.023	+4.273	<.001	.006	3	1
BLOOD_Leukemia	CST9L →	+0.461	+3.684	<.001	.004	3	1
BLOOD_Leukemia	OR4K2 →	+0.020	+3.969	<.001	.009	3	1
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	BPIFB3 →	+0.106	+3.289	<.001	.009	3	1
BLOOD_Leukemia	KRT222 →	+0.835	+3.813	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACCSL by PDPN expression — LARGE_INTESTINE

Explore this box plot interactively →