PDPK1

Across TCGA patient cohorts, PDPK1 mutation is significantly associated with the RNA expression of many other genes, with 1,781 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDPK1-associated genes across cancer lineages are MIR1227, TAF9, and RNA5SP411. Each is linked with PDPK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDPK1-to-partner and partner-to-PDPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1227 grouped by PDPK1-low versus PDPK1-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPK1→partner) and Y-score (partner→PDPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	MIR1227 →	+0.375	+5.954	<.001	.002	3	3
UCEC	TAF9 →	+0.558	+3.721	<.001	<.001	3	2
UCEC	RNA5SP411 →	+0.673	+1.978	.004	<.001	3	2
UCEC	RNA5SP423 →	+0.453	+1.639	.005	.006	3	2
UCEC	PRAMEF13 →	+0.024	+2.868	<.001	.002	3	2
UCEC	CCDC116 →	+0.252	+2.202	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,781 associations by consensus.

MIR1227 by PDPK1 expression — ESCA

Explore this box plot interactively →