PDPK1

Across TCGA cell cohorts, PDPK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,770 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDPK1-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Cytosolic transport, and Peptidyl-serine modification. Each is linked with PDPK1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PDPK1-to-partner and partner-to-PDPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by PDPK1-low versus PDPK1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPK1→partner) and Y-score (partner→PDPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Symbiont-mediated disruption of host cell PML body →	+0.126	+1.179	<.001	<.001	3	18
STOMACH	Cytosolic transport →	+0.085	+1.164	<.001	<.001	3	14
LUNG_SCLC	Peptidyl-serine modification →	+0.069	+0.428	.001	.007	3	14
LUNG_SCLC	Regulation of chromatin organization →	+0.109	+0.602	<.001	<.001	3	14
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.106	+0.550	.002	.001	3	14
BREAST	Regulation of mitotic cytokinetic process →	+0.137	+0.909	.001	.003	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,770 associations by consensus.

Symbiont-mediated disruption of host cell PML body by PDPK1 expression — STOMACH

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