PDPK1

Across TCGA cell cohorts, PDPK1 mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDPK1-associated genes across cancer lineages are FAM236A, TRPC7, and OR56A5. Each is linked with PDPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDPK1-to-partner and partner-to-PDPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM236A grouped by PDPK1-low versus PDPK1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPK1→partner) and Y-score (partner→PDPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM236A →	+0.048	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	TRPC7 →	+0.055	+3.770	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
LARGE_INTESTINE	NISCH →	+0.633	+3.364	.009	.002	3	1
LARGE_INTESTINE	NOP2 →	+0.559	+3.169	.007	.009	3	1
LARGE_INTESTINE	RSPH4A →	+0.217	+3.451	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

FAM236A by PDPK1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →