PDP2

Across TCGA patient cohorts, PDP2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDP2-associated genes across cancer lineages are STAT3_pY705, ATM, and P-Cadherin. Each is linked with PDP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDP2-to-partner and partner-to-PDP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PDP2-low versus PDP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDP2→partner) and Y-score (partner→PDP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.348	-1.765	<.001	.014	3	2
UCEC	ATM →	-0.530	-1.765	.001	.014	3	2
SKCM	P-Cadherin →	+0.288	+3.000	.047	.036	3	1
UCEC	14-3-3_beta →	-0.102	-3.558	.006	.002	3	1
UCEC	EGFR →	-0.160	-2.321	.007	.034	3	1
UCEC	eIF4E →	+0.246	+2.662	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

STAT3_pY705 by PDP2 expression — UCEC

Explore this box plot interactively →