PDLIM5

Across TCGA patient cohorts, PDLIM5 mutation is significantly associated with the RNA expression of many other genes, with 4,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDLIM5-associated genes across cancer lineages are SCG5-AS1, MIR4444-2, and WHAMM. Each is linked with PDLIM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDLIM5-to-partner and partner-to-PDLIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCG5-AS1 grouped by PDLIM5-low versus PDLIM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM5→partner) and Y-score (partner→PDLIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCG5-AS1 →	+0.156	+1.579	.002	.007	3	3
LIHC	MIR4444-2 →	+0.642	+5.119	<.001	.001	3	3
UCEC	WHAMM →	+0.686	+2.839	<.001	<.001	3	2
SKCM	ADPGK →	+0.481	+3.350	.005	.005	3	2
UCEC	PCNT →	+0.368	+2.432	.003	<.001	3	2
UCEC	ATXN7 →	+0.403	+2.272	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,101 associations by consensus.

SCG5-AS1 by PDLIM5 expression — UCEC

Explore this box plot interactively →