PDLIM5

Across TCGA cell cohorts, PDLIM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,931 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDLIM5-associated GO terms across cancer lineages are Physiological muscle hypertrophy, Physiological cardiac muscle hypertrophy, and Cell growth involved in cardiac muscle cell development. Each is linked with PDLIM5 in more than 14 cancer types. Because this analysis shows association rather than direction, both PDLIM5-to-partner and partner-to-PDLIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Physiological muscle hypertrophy grouped by PDLIM5-low versus PDLIM5-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM5→partner) and Y-score (partner→PDLIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Physiological muscle hypertrophy →	+1.213	+1.692	<.001	<.001	3	15
BLOOD_Leukemia	Physiological cardiac muscle hypertrophy →	+1.213	+1.692	<.001	<.001	3	15
BLOOD_Leukemia	Cell growth involved in cardiac muscle cell development →	+1.213	+1.692	<.001	<.001	3	15
LUNG_SCLC	Positive regulation of protein exit from endoplasmic reticulum →	+0.127	+1.863	<.001	<.001	3	13
LIVER	Cell-substrate junction organization →	+0.156	+1.203	.001	<.001	3	12
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.071	+1.316	.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,931 associations by consensus.

Physiological muscle hypertrophy by PDLIM5 expression — BLOOD_Leukemia

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