PDLIM5

Across TCGA cell cohorts, PDLIM5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDLIM5-associated genes across cancer lineages are AVP, OR10W1, and OR10Q1. Each is linked with PDLIM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDLIM5-to-partner and partner-to-PDLIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by PDLIM5-low versus PDLIM5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM5→partner) and Y-score (partner→PDLIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	OR10Q1 →	+0.077	+3.242	.009	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.106	+3.103	.007	.004	3	1
LUNG_NSCLC_LUAD	MBD3L2 →	+0.151	+5.228	<.001	.005	3	1
BLOOD_Lymphoma	SERPINB12 →	+0.117	+3.714	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

AVP by PDLIM5 expression — LARGE_INTESTINE

Explore this box plot interactively →