PDLIM3

Across TCGA pan-cancer cohorts, PDLIM3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDLIM3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PDLIM3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDLIM3 expression acts as an unfavorable survival marker.

LSCC, PDAC, and CCRCC are the cancer types where PDLIM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.546	1.000	.004	19	view →
PDAC	DFS	Quartile	III,IV	0.227	0.904	.006	13	view →
CCRCC	DFS	Quartile	III,IV	0.140	0.887	.038	6	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	6	view →
GBM	OS	Quartile	All	0.330	0.654	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDLIM3–LSCC (DFS)

Open the LSCC breakdown →