PDLIM3

Across TCGA patient cohorts, PDLIM3 mutation is significantly associated with the RNA expression of many other genes, with 1,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDLIM3-associated genes across cancer lineages are PSAT1P4, NCOA4P1, and SMIM12P1. Each is linked with PDLIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDLIM3-to-partner and partner-to-PDLIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by PDLIM3-low versus PDLIM3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM3→partner) and Y-score (partner→PDLIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PSAT1P4 →	+0.183	+4.157	<.001	.003	3	2
LUAD	NCOA4P1 →	+0.049	+4.231	.005	.003	3	2
BLCA	SMIM12P1 →	+0.119	+5.033	<.001	.003	3	2
UCEC	UHRF1 →	+0.839	+2.673	<.001	<.001	3	2
UCEC	BRI3BP →	+0.603	+2.180	.001	.002	3	2
UCEC	CALHM6 →	+0.942	+2.415	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,382 associations by consensus.

PSAT1P4 by PDLIM3 expression — LUAD

Explore this box plot interactively →