PDLIM3

Across TCGA patient cohorts, PDLIM3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDLIM3-associated genes across cancer lineages are 14-3-3_beta, ERK2, and MEK1. Each is linked with PDLIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDLIM3-to-partner and partner-to-PDLIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PDLIM3-low versus PDLIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM3→partner) and Y-score (partner→PDLIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.127	-3.432	.002	.005	3	2
UCEC	ERK2 →	+0.256	+2.700	.001	.006	3	2
UCEC	MEK1 →	+0.422	+3.584	.005	.002	3	2
UCEC	Annexin-1 →	+0.566	+1.894	.009	.030	3	2
UCEC	Di-Ras3 →	-0.137	-2.986	.025	.035	3	2
COAD	GSK3-a-b →	+0.180	+2.849	.031	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by PDLIM3 expression — UCEC

Explore this box plot interactively →