PDLIM3

Across TCGA cell cohorts, PDLIM3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PDLIM3-associated genes across cancer lineages are SPINK9, FGF6, and ANKRD60. Each is linked with PDLIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDLIM3-to-partner and partner-to-PDLIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by PDLIM3-low versus PDLIM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM3→partner) and Y-score (partner→PDLIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPINK9 →	+0.333	+3.793	<.001	.007	3	1
CNS	FGF6 →	+0.033	+4.981	.003	.008	3	1
CNS	ANKRD60 →	+0.063	+6.357	<.001	<.001	3	1
LUNG_NSCLC_LUAD	LRRC74A →	+0.008	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	R3HDML →	+0.170	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	SAGE1 →	+1.561	+3.514	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SPINK9 by PDLIM3 expression — LARGE_INTESTINE

Explore this box plot interactively →