PDLIM3

Across TCGA cell cohorts, PDLIM3 mutation is significantly associated with the mutation status of many other genes, with 1,633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDLIM3-associated genes across cancer lineages are EVC2, KCNB2, and MBD5. Each is linked with PDLIM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDLIM3-to-partner and partner-to-PDLIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVC2 grouped by PDLIM3-low versus PDLIM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM3→partner) and Y-score (partner→PDLIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EVC2 →	+2.284	+3.925	.005	.005	1	3
LARGE_INTESTINE	KCNB2 →	+2.284	+3.925	.005	.005	1	3
LUNG_NSCLC_LUAD	MBD5 →	+2.981	+3.266	.009	.009	1	3
LARGE_INTESTINE	MAST2 →	+2.159	+3.807	.007	.007	1	3
LARGE_INTESTINE	TRPM2 →	+2.159	+3.807	.007	.007	1	3
LARGE_INTESTINE	CAPN10 →	+2.744	+4.321	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,633 associations by consensus.

EVC2 by PDLIM3 expression — LARGE_INTESTINE

Explore this box plot interactively →