PDLIM2

Across TCGA cell cohorts, PDLIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,505 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDLIM2-associated GO terms across cancer lineages are Calcineurin-NFAT signaling cascade, Peptidyl-lysine oxidation, and Positive regulation of supramolecular fiber organization. Each is linked with PDLIM2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PDLIM2-to-partner and partner-to-PDLIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcineurin-NFAT signaling cascade grouped by PDLIM2-low versus PDLIM2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM2→partner) and Y-score (partner→PDLIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Calcineurin-NFAT signaling cascade →	+0.067	+1.503	.004	<.001	3	12
BONE	Peptidyl-lysine oxidation →	+1.605	+4.351	<.001	<.001	3	11
BONE	Positive regulation of supramolecular fiber organization →	+0.084	+3.983	<.001	<.001	3	10
BONE	Positive regulation of stress fiber assembly →	+0.188	+3.813	<.001	<.001	3	10
BONE	Positive regulation of cell-substrate junction organization →	+0.178	+3.466	<.001	<.001	3	10
URINARY_TRACT	Positive regulation of synapse structural plasticity →	+1.334	+2.038	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,505 associations by consensus.

Calcineurin-NFAT signaling cascade by PDLIM2 expression — LIVER

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