PDLIM1

Across TCGA patient cohorts, PDLIM1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDLIM1-associated genes across cancer lineages are PDCD4, S6_pS240_S244, and ASNS. Each is linked with PDLIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDLIM1-to-partner and partner-to-PDLIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PDLIM1-low versus PDLIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM1→partner) and Y-score (partner→PDLIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.596	-2.415	.001	.003	3	2
UCEC	S6_pS240_S244 →	+0.487	+3.584	.002	.002	3	2
UCEC	ASNS →	+0.517	+2.584	<.001	.010	3	2
UCEC	ATM →	-0.540	-1.906	.003	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.956	+2.415	<.001	.003	3	2
SKCM	ACVRL1 →	+0.223	+2.840	.007	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PDCD4 by PDLIM1 expression — UCEC

Explore this box plot interactively →