PDLIM1

Across TCGA cell cohorts, PDLIM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,167 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PDLIM1-associated GO terms across cancer lineages are Establishment or maintenance of actin cytoskeleton polarity, Cell-substrate junction assembly, and Fibroblast migration. Each is linked with PDLIM1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PDLIM1-to-partner and partner-to-PDLIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment or maintenance of actin cytoskeleton polarity grouped by PDLIM1-low versus PDLIM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM1→partner) and Y-score (partner→PDLIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Establishment or maintenance of actin cytoskeleton polarity →	+0.313	+2.936	.001	<.001	3	14
LUNG_NSCLC_LUSC	Cell-substrate junction assembly →	+0.193	+2.345	.002	.002	3	13
STOMACH	Fibroblast migration →	+0.245	+2.716	<.001	.002	3	12
LUNG_NSCLC_LUSC	Cell-substrate junction organization →	+0.200	+2.185	<.001	<.001	3	12
BONE	Maintenance of cell polarity →	+0.176	+4.737	<.001	<.001	3	12
BONE	Blood coagulation, extrinsic pathway →	+1.604	+4.051	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,167 associations by consensus.

Establishment or maintenance of actin cytoskeleton polarity by PDLIM1 expression — BONE

Explore this box plot interactively →