PDK4

Across TCGA pan-cancer cohorts, PDK4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PDK4 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PDK4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDK4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where PDK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.809	1.000	.012	10	view →
LUAD	DFS	Quartile	III,IV	0.920	0.462	.013	5	view →
PDAC	DFS	Quartile	II,III,IV	0.656	0.361	.034	4	view →
LSCC	DFS	Median	II,III,IV	1.000	0.356	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PDK4–CCRCC (DFS)

Open the CCRCC breakdown →