PDK4

Across TCGA patient cohorts, PDK4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDK4-associated genes across cancer lineages are ERK2, P-Cadherin, and Annexin-1. Each is linked with PDK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDK4-to-partner and partner-to-PDK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PDK4-low versus PDK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK4→partner) and Y-score (partner→PDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.196	+2.000	.003	.009	3	2
UCEC	P-Cadherin →	-0.117	-2.321	.021	.033	3	2
UCEC	Annexin-1 →	+0.591	+2.135	.001	.010	3	2
UCEC	ATM →	-0.590	-2.000	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.084	-1.780	.018	.024	3	1
UCEC	EGFR_pY1068 →	-0.249	-2.115	.004	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by PDK4 expression — UCEC

Explore this box plot interactively →