PDK4

Across TCGA cell cohorts, PDK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,066 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PDK4-associated GO terms across cancer lineages are Energy derivation by oxidation of organic compounds, Regulation of myoblast fusion, and Oxidative phosphorylation. Each is linked with PDK4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PDK4-to-partner and partner-to-PDK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy derivation by oxidation of organic compounds grouped by PDK4-low versus PDK4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK4→partner) and Y-score (partner→PDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Energy derivation by oxidation of organic compounds →	+0.054	+0.295	.001	.006	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.102	+0.440	<.001	.005	3	7
CNS	Oxidative phosphorylation →	+0.061	+0.736	<.001	.002	3	7
LARGE_INTESTINE	Response to cAMP →	+0.052	+0.908	.001	<.001	3	6
LUNG_NSCLC_LUAD	Flavin-containing compound metabolic process →	+0.091	+1.325	<.001	<.001	3	6
OVARY	Lysosomal lumen acidification →	+0.092	+1.211	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,066 associations by consensus.

Energy derivation by oxidation of organic compounds by PDK4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →