PDK4

Across TCGA cell cohorts, PDK4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDK4-associated genes across cancer lineages are OR10K2, PABPC1L2A, and OR10T2. Each is linked with PDK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDK4-to-partner and partner-to-PDK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K2 grouped by PDK4-low versus PDK4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK4→partner) and Y-score (partner→PDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
LARGE_INTESTINE	KCND3 →	+0.302	+3.519	.008	.007	3	1
LARGE_INTESTINE	HTR3A →	+0.595	+3.392	.002	.007	2	1
LARGE_INTESTINE	UBE2QL1 →	+0.246	+3.044	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR10K2 by PDK4 expression — BREAST

Explore this box plot interactively →