PDK3

Across TCGA pan-cancer cohorts, PDK3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDK3 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDK3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDK3 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where PDK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.632	0.891	.013	57	view →
PDAC	OS	Quartile	All	0.690	0.373	.015	14	view →
CCRCC	DFS	Tertile	II,III,IV	0.409	0.736	.026	8	view →
LUAD	OS	Median	All	0.602	0.821	.031	6	view →
GBM	OS	Quartile	All	0.277	0.542	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDK3–HNSC (OS)

Open the HNSC breakdown →