PDK3

Across TCGA patient cohorts, PDK3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDK3-associated genes across cancer lineages are p62 Lck ligand, PCNA, and ATM. Each is linked with PDK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDK3-to-partner and partner-to-PDK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PDK3-low versus PDK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK3→partner) and Y-score (partner→PDK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.470	+3.009	<.001	<.001	3	2
UCEC	PCNA →	+0.213	+2.700	.003	.005	3	2
UCEC	ATM →	-0.334	-1.906	.028	.015	3	2
UCEC	Cyclin-B1 →	+0.647	+2.807	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.170	-1.321	.042	.029	3	1
UCEC	eIF4E →	+0.224	+2.584	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p62 Lck ligand by PDK3 expression — UCEC

Explore this box plot interactively →