PDK2

Across TCGA pan-cancer cohorts, PDK2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PDK2 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PDK2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PDK2 expression acts as an unfavorable survival marker.

KICH, LUAD, and COAD are the cancer types where PDK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.161	0.881	<.001	24	view →
LUAD	DFS	Median	III,IV	0.206	0.670	.015	9	view →
COAD	OS	Median	All	0.210	0.799	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PDK2–KICH (OS)

Open the KICH breakdown →